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Study identifier: NCT05805774 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

pDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement

Condition: Distal Femur Fracture · Periprosthetic Fracture Around Prosthetic Joint Implant Knee · Knee Fracture  ·  Sponsor: Unity Health Toronto

PhaseNA
Planned participants148
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersNo

About this study

Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of your fractured bone. The second method consists in replacing your knee joint with an artificial knee prosthesis (artificial knee joint). The primary objective is to determine if acute distal femur replacement improves knee pain and functional outcomes compared to surgical fixation. Secondary outcomes are mortality, reoperation, complications, post-operative pain and quality of life. A health economic analysis will be conducted to assess the cost-effectiveness of both treatments. A total of 148 patients (74/group) will be enrolled in the study.

This description comes directly from the study's public registry record.

Talk to the study team

Cassandra Tardif-Theriault  ·  416-864-6060  ·  cassandra.tardif-theriault@unityhealth.to

Always discuss trial participation with your own doctor first.

Locations (1)

St. Michael's HospitalToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05805774