Condition: Acute Kidney Injury · Sponsor: University of Pittsburgh
The COPE-AKI study is a randomized, pragmatic, parallel-arm trial comparing a multimodal intervention to usual care on hospital-free days through 90 days of study follow up. The primary study hypothesis is that patients randomized to the intervention will have increased odds of more hospital-free days through 90 days (primary clinical) compared to those randomized to usual care. Key secondary hypotheses will investigate the impact of the intervention on rates of major adverse kidney events, rates of recurrent AKI, and changes in patient-reported outcomes. Participants (N=2145) will be allocated 1:1 to the intervention or usual care using a web-based system to maintain allocation concealment using stratified randomization with randomly permuted blocks. Randomization will be stratified by clinical site.
This description comes directly from the study's public registry record.
Susan J Copelli, MSHI · 412-245-0803 · sju1@pitt.edu
Kaleab Abebe, PhD · kza3@pitt.edu
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| Cleveland Clinic Weston Hospital | Weston, Florida, United States | Recruiting |
| University of Maryland | Baltimore, Maryland, United States | Recruiting |
| Johns Hopkins University | Baltimore, Maryland, United States | Recruiting |
| MetroHealth | Cleveland, Ohio, United States | Recruiting |
| Cleveland Clinic Foundation | Cleveland, Ohio, United States | Recruiting |
| Nashville VA Medical Center | Nashville, Tennessee, United States | Recruiting |
| Vanderbilt University | Nashville, Tennessee, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05805709