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Study identifier: NCT05804669 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Condition: Cushing Syndrome · Cushing Disease · Ectopic ACTH Syndrome  ·  Sponsor: Crinetics Pharmaceuticals Inc.

PhasePhase 1/Phase 2
Planned participants18
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A Phase 1b/2a, first-in-disease, open-label, multiple-ascending dose exploratory study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamic biomarker responses associated with CRN04894 (an adrenocorticotropic hormone \[ACTH\] receptor antagonist) in participants with ACTH-dependent Cushing's syndrome (Cushing's disease or Ectopic ACTH Syndrome \[EAS\])

This description comes directly from the study's public registry record.

Talk to the study team

Crinetics Clinical Trials  ·  833-827-9741  ·  clinicaltrials@crinetics.com

Always discuss trial participation with your own doctor first.

Locations (1)

National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Bethesda, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05804669