Condition: Metastatic Colorectal Carcinoma · Metastatic Malignant Solid Neoplasm · Stage IV Colorectal Cancer AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and that it has progressed on previous standard treatment. ZEN003694 is an inhibitor of a family of proteins called the bromodomain and extra-terminal (BET). It may prevent the growth of tumor cells that over produce BET protein. Capecitabine is in a class of medications called antimetabolites. It is taken up by cancer cells and breaks down into fluorouracil, a substance that kills cancer cells. Giving ZEN003694 in combination with capecitabine may be safe in treating patients with metastatic or unresectable solid tumors.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| UF Health Cancer Institute - Gainesville | Gainesville, Florida, United States | Recruiting |
| Memorial Hospital East | Shiloh, Illinois, United States | Active Not Recruiting |
| University of Kansas Clinical Research Center | Fairway, Kansas, United States | Recruiting |
| University of Kansas Cancer Center | Kansas City, Kansas, United States | Recruiting |
| University of Kansas Hospital-Westwood Cancer Center | Westwood, Kansas, United States | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters, Missouri, United States | Active Not Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, United States | Active Not Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Active Not Recruiting |
| Siteman Cancer Center-South County | St Louis, Missouri, United States | Active Not Recruiting |
| Siteman Cancer Center at Christian Hospital | St Louis, Missouri, United States | Active Not Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05803382