Condition: Bipolar Disorder · Sponsor: Assistance Publique - Hôpitaux de Paris
Bipolar Disorder (BD) is a severe mood disorder affecting between 1% and 3% of the general population. It is characterized by the succession of depressive and manic episodes, with periods of stabilization during which patients may present "residual" depressive or anxious symptoms, which are characterized by sadness and emotional hyper-reactivity. Although subthreshold, these residual symptoms are very disabling for their daily lives and are associated with the risk of recurrence and poor global functioning. The effect of pharmacological and psychotherapeutic treatments is demonstrated in the management of acute episodes but remains insufficient on residual symptoms. Therefore, there are so far few therapeutic options to target the inter-episode residual symptoms in BD. One novel approach is the real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB), which has already been shown to be an efficient method for self-regulating brain function, behavior and treating depression. Hypothesis/Objective : This study aims at assessing the efficacy of 3-weeks neurofeedback training with real-time fMRI on the treatment of residual mood symptoms in patients with BD. The investigators will specifically target depressive symptoms by training the patients to regulate the emotional network hemodynamic response to emotional stimuli. Method : The investigators will include 64 stabilized patients with BD. The investigators will recruit them in three French expert centers fo…
This description comes directly from the study's public registry record.
Josselin HOUENOU, Professor (MD, PhD) · (+33)1 49 81 30 51 · josselin.houenou@aphp.fr
Pauline Favre, Associate researcher (PhD) · (+33)1 69 08 24 81 · pauline.favre@cea.fr
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| Albert Chenevier | Créteil, val-de-marne, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05802446