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Study identifier: NCT05799105 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers

Condition: Marginal Ulcer  ·  Sponsor: Stephen Firkins

PhasePhase 4
Planned participants122
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to identify the most effective way to take acid-blocking medications to treat stomach ulcers in patients who have undergone gastric bypass surgery. The main questions it aims to answer are: * is taking an acid-blocking medication by opening the capsule and only taking the contents of the capsule (open-capsule) more or less effective than taking the capsule as a whole (intact-capsule) for treating ulcers in patients who have a history of gastric bypass surgery? * does taking the open versus intact medication decrease the number of procedures and complications from untreated ulcers? Participants with ulcers will be instructed to take acid-blocking medications (called proton-pump inhibitors) either by opening the capsule and taking only the contents or by taking the capsule whole. These medications are the gold standard for treatment of stomach ulcers. Participants will be asked to undergo an upper endoscopy (EGD) every 3 months to monitor the healing of the ulcers. Researchers will compare how quickly the ulcers heal depending on which way the medications are taken (opened up or as a whole).

This description comes directly from the study's public registry record.

Talk to the study team

Stephen Firkins, MD  ·  216-444-8460  ·  bariatricendoscopy@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland Clinic FoundationCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05799105