Household Transmission Dynamics of Multidrug Resistant Enterobacterales

The HOME study will prospectively follow a cohort of Multi-Drug Resistant Enterobacterales (MDR-E) carriers after hospital discharge, and their related household members over a 3-month period. The main objective is to estimate the rate of confirmed transmissions of MDR-E from the index cases to related household members, and identify predictors associated with transmission. Transmission will be confirmed by comparing genomic analysis of the MDR-E strains isolated both in the index patient and his/her household members, based on the number of Single nucleotide polymorphisms (SNPs) differences between nearby genomes by Variant Calling. Multifactorial processes involved in MDR-E transmission in households will be explored with stochastic individual-based modelling. The parameterized model will be used to simulate and assess different strategies of control of MDR-E emergence and transmission to households. The impact of modifying patterns of human-contacts, promote hygiene and control barriers (decontamination of objects or surfaces, variations in antibiotic use, reinforcement of hand hygiene) will be assessed.

This description comes directly from the study's public registry record.

Kernéis Solen, MD, PhD  ·  +33 1 40 25 61 99  ·  solen.kerneis@aphp.fr

Armand-Lefevre Laurence, Pharm. D., PhD.  ·  +33 1 40 25 85 00  ·  laurence.armand@aphp.fr

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