Condition: Rectal Carriage of Carbapenemase Producing-Enterobacteriaceae · Sponsor: Assistance Publique - Hôpitaux de Paris
"The emergence and spread of highly resistant bacteria, including carbapenemase-producing Enterobacteriaceae (CPE), is a public health challenge given their rapid spread and the lack of active antibiotics against these bacteria. The spread of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE) since the early 2000s raises concerns about a potential similar spread of CPE in the coming years, especially in the healthcare setting. Early detection of CPE carriage in hospitalized patients with risk factors for CPE carriage is essential to prevent their spread in hospitals as well as to guide empiric antibiotic therapy for CPE carriers with signs of severe infection. However, the prevalence of CPE carriage on admission to hospital is not precisely known, nor are factors associated with CPE carriage. Hence, the investigators sought to determine the prevalence of CPE carriage and its risk factors in patients admitted to hospital, in order to identify the appropriate indications for CPE screening on admission to hospital. Secondly, the investigators aimed to estimate the annual number of patients with CPE carriage who would not have been identified with the current targeted screening policy as well as to estimate the annual number of secondary cases that could be prevented if a universal screening policy was applied on admission (i.e. for all hospitalized patients, not just those with risk factors). Therefore, the investigators plan to carry out a systematic screening…
This description comes directly from the study's public registry record.
Solen Kernéis, MD - PhD · 33140256199 · solen.kerneis@aphp.fr
Claire Durand, MD · 33686016726 · durand.c@chu-nice.fr
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| Bichat Hospital | Paris, Île-de-France Region, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05798351