← Eichor
Study identifier: NCT05797831 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

Condition: Endometrial Cancer  ·  Sponsor: Kartos Therapeutics, Inc.

PhasePhase 2/Phase 3
Planned participants268
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.

This description comes directly from the study's public registry record.

Talk to the study team

John Mei  ·  650-542-0136  ·  jmei@kartosthera.com

Always discuss trial participation with your own doctor first.

Locations (83)

Kaiser Permanente CenterVallejo, California, United StatesRecruiting
Northside HospitalAtlanta, Georgia, United StatesRecruiting
St. JosephSavannah, Georgia, United StatesRecruiting
Dr. Sudarshan K. Sharma, Ltd.Hinsdale, Illinois, United StatesRecruiting
Parkview Research CenterFort Wayne, Indiana, United StatesRecruiting
Indiana UniversityIndianapolis, Indiana, United StatesRecruiting
Maryland Oncology Hematology, P.A.Silver Spring, Maryland, United StatesRecruiting
Minnesota Oncology Hematology, P.A.Minneapolis, Minnesota, United StatesRecruiting
Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting
Women's Cancer Center of NevadaLas Vegas, Nevada, United StatesRecruiting
Good Samaritan Hospital Medical CenterWest Islip, New York, United StatesRecruiting
FirstHealth CarolinasPinehurst, North Carolina, United StatesRecruiting

+ 71 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05797831