← Eichor
Study identifier: NCT05797610 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

Condition: Primary IgA Nephropathy  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants428
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: WA43966 https://forpatients.roche.com/  ·  888-662-6728 (U.S. Only)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. No email attachments. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (204)

Alabama Kidney Research - ERN - PPDSAlabaster, Alabama, United StatesRecruiting
UAB Nephrology Research ClinicBirmingham, Alabama, United StatesRecruiting
Sunrise Medical Management LLCSurprise, Arizona, United StatesWithdrawn
Tucson Neuroscience Research - M3 WRTucson, Arizona, United StatesWithdrawn
Kidney Disease Medical Group Inc-1505 Wilson TerGlendale, California, United StatesRecruiting
Southern California Medical Research CenterLa Palma, California, United StatesWithdrawn
Academic Medical Research Institute - Los AngelesLos Angeles, California, United StatesRecruiting
University of California, Los Angeles (UCLA) - Hematology/Oncology Santa MonicaLos Angeles, California, United StatesRecruiting
Los Angeles County NephrologyMontebello, California, United StatesRecruiting
North America Research Institute-San DimasSan Dimas, California, United StatesRecruiting
Kaiser Permanente Skyport Medical OfficesSan Jose, California, United StatesRecruiting
BioResearch Partner ? Jackson WestDoral, Florida, United StatesRecruiting

+ 192 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05797610