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Study identifier: NCT05796570 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies

Condition: Acute Myeloid Leukemia · Myelodysplastic Syndromes · Myeloid Malignancies  ·  Sponsor: Franziska Wachter

PhasePhase 2
Planned participants37
Who can joinAll sexes, 1 Year to 39 Years
Healthy volunteersNo

About this study

The purpose of this study is to examine if it is feasible to administer decitabine and filgrastim after allogenic hematopoietic stem cell transplant (HCT) in children and young adults with myelodysplastic syndrome, acute myeloid leukemia and related myeloid disorders, and if the treatment is effective in preventing relapse after HCT. The names of the study drugs involved in this study are: * Decitabine (a nucleoside metabolic inhibitor) * Filgrastim (a recombinant granulocyte colony-stimulating factor (G-CSF)

This description comes directly from the study's public registry record.

Talk to the study team

Franziska Wachter, MD  ·  617-632-4583  ·  franziska_wachter@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05796570