Condition: Psychosis · Sponsor: Centre Hospitalier St Anne
Chronic psychosis, including schizophrenia is now viewed as a progressive disorder where cognitive deficits predate the clinical onset. Early intervention programs improve the general outcome with staged care strategies, supporting the view that the period before and around the first episode of psychosis is a window of opportunity for improving its functional recovery. Pioneering epigenetic analyses indicate that psychosis onset involves oxidative stress and inflammation suggesting that neuroprotective strategies could limit or even prevent the onset of or the transition into a chronic disorder. Several biological factors associated with the emergence of psychosis can all be rectified by using safe and easily accepted supplements including alterations folate deficiency/hyperhomocysteinemia; redox imbalance and deficit in polyunsaturated fatty acids (PUFA). The prevalence of these anomalies (20-30%) justifies a systematic detection and could guide personalised add-on strategy. Cognitive remediation improves quality of life (QoL) and functional outcome in patients with chronic psychosis. It would even be more efficacious in the early phase of psychosis by tackling the negative impact of psychosis on education achievement and employment. However, cognitive dysfunctions are often overlooked in patients at ultra-high risk (UHR) for psychosis and patient with a first episode of psychosis (FEP) and cognitive remediation is not always accessible. New technologies can provide us wit…
This description comes directly from the study's public registry record.
Marie-Odile KREBS · +33 1 45 65 74 97 · marie-odile.krebs@inserm.fr
Khaoussou SYLLA · +331.45.65.73.35 · K.SYLLA@ghu-paris.fr
Always discuss trial participation with your own doctor first.
| CHRU Brest | Brest, France | Recruiting |
| Centre Esquirol - CHU CAEN | Caen, France | Recruiting |
| CHU Clermont Ferrand | Clermont-Ferrand, France | Recruiting |
| Centre Hospitalier La Chartreuse | Dijon, France | Not Yet Recruiting |
| Hôpital Fontan | Lille, France | Recruiting |
| Hôpital La Colombière - CHU Montpellier | Montpellier, France | Recruiting |
| Eldorado - Maison des Adolescents de Meurthe et Moselle | Nancy, France | Recruiting |
| CH Orsay | Orsay, France | Recruiting |
| GHU Paris Neurosciences Psychiatrie | Paris, France | Recruiting |
| Nineteen GHU | Paris, France | Not Yet Recruiting |
| CHU Poitiers | Poitiers, France | Recruiting |
| C.H. Guillaume Regnier | Rennes, France | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05796401