● Recruiting

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Condition: Non-Small Cell Lung Cancer · Sponsor: Hoffmann-La Roche

PhasePhase 1/Phase 2

Planned participants320

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of single-agent divarasib or combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: BO44426 https://forpatients.roche.com/ No attachments to email below. · 888-662-6728 (U.S. and Canada) · global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (71)

City of Hope National Medical Center	Duarte, California, United States	Withdrawn
City of Hope - Seacliff	Huntington Beach, California, United States	Withdrawn
City of Hope at Irvine Lennar	Irvine, California, United States	Withdrawn
UCSD Moores Cancer Center	La Jolla, California, United States	Withdrawn
City of Hope - Long Beach Elm	Long Beach, California, United States	Withdrawn
Yale Cancer Center	New Haven, Connecticut, United States	Recruiting
Florida Cancer Specialists - SOUTH - SCRI - PPDS	Fort Myers, Florida, United States	Recruiting
Florida Cancer Specialists - NORTH - SCRI - PPDS	St. Petersburg, Florida, United States	Recruiting
Florida Cancer Specialists - EAST - SCRI - PPDS	West Palm Beach, Florida, United States	Recruiting
NYU Langone Hospital - Long Island	Mineola, New York, United States	Recruiting
NYU Cancer Center	New York, New York, United States	Recruiting
Mount SInai Medical Center	New York, New York, United States	Recruiting

+ 59 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05789082