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Study identifier: NCT05784428 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Single vs. Multiple Fraction Trial of Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastases/Progression

Condition: Oligometastatic Disease · Oligoprogression · Toxicity Due to Radiotherapy  ·  Sponsor: Robert Olson

PhaseNA
Planned participants598
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Stereotactic Ablative Radiotherapy (SABR) is a modern RT technique that delivers high doses of radiation to small tumor targets using highly conformal techniques, while trying to avoid healthy tissues and organs. However, SABR treatment requires increased planning, treatment time, cost and potential for higher toxicity due to the higher dose. The purpose of this study is to compare single fraction (SF) SABR vs. multiple fraction (MF) SABR in regards to toxicities, progression-free survival, quality of life (QoL), and cost-effectiveness. In a subset of patients, we will also compare patient QoL, hospitalization rates, and cost-effectiveness between patients who complete QoL questionnaires, record symptoms and receive healthcare provider-guided intervention vs. patients who complete QoL questionnaires only.

This description comes directly from the study's public registry record.

Talk to the study team

Robert Olson, MD, MSC, FRCPC  ·  250-645-7300  ·  rolson2@bccancer.bc.ca

Jordanna Laing, MSc  ·  250-645-7300  ·  jordanna.laing@bccancer.bc.ca

Always discuss trial participation with your own doctor first.

Locations (14)

BC CancerKelowna, British Columbia, CanadaRecruiting
BC CancerPrince George, British Columbia, CanadaRecruiting
BC CancerSurrey, British Columbia, CanadaRecruiting
BC CancerVancouver, British Columbia, CanadaRecruiting
BC Cancer - VictoriaVictoria, British Columbia, CanadaNot Yet Recruiting
Health Sciences North Research InstituteGreater Sudbury, Ontario, CanadaRecruiting
Princess Margaret Cancer Centre | University Health NetworkToronto, Ontario, CanadaRecruiting
University Hospital GalwayGalway, Connacht, IrelandRecruiting
St. Luke's Radiation Oncology NetworkDublin, Dublin, IrelandRecruiting
Mater Private HospitalDublin, Leinster, IrelandRecruiting
Beacon HospitalDublin, Leinster, IrelandRecruiting
Cork University HospitalCork, Munster, IrelandRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05784428