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Study identifier: NCT05783323 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer

Condition: Differentiated Thyroid Cancer · Pediatric Cancer · Cancer  ·  Sponsor: Children's Hospital of Philadelphia

PhasePhase 2
Planned participants13
Who can joinAll sexes, 2 Years to 99 Years
Healthy volunteersNo

About this study

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less than a quarter of patients with lung metastases will achieve a complete response to RAI therapy, and this therapy carries the risk of pulmonary fibrosis and an increasingly recognized risk of secondary malignancies.

This description comes directly from the study's public registry record.

Talk to the study team

Meghan Donnelly  ·  267-426-9343  ·  donnellymt@chop.edu

James Robinson  ·  215-590-2053  ·  robinsonj9@chop.edu

Always discuss trial participation with your own doctor first.

Locations (5)

University of California, San FranciscoSan Francisco, California, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
St. Jude Children's Research HospitalMemphis, Tennessee, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Seattle Children's HospitalSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05783323