Condition: Crohn Disease · Sponsor: Connecticut Children's Medical Center
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both. CD may be associated with abdominal cramps/pain, diarrhea, blood in the stool, weight loss, or delayed growth in children. While the exact cause of CD is not certain it is thought that the immune system located in the intestine reacts abnormally to the large number of bacteria contained there. The investigators think that diet, exposure to antibiotics early in life, and having a family history of CD puts people at increased risk for developing CD. In order to decrease the inflammation doctors use what is called biologic therapy with anti-TNF molecules that can be given through an intravenous or shots. TNF is a chemical made by white blood cells that is involved in inflammation. When this type of treatment is given early after diagnosis it is more effective than when it is given later. The investigators have learned that it is important to give the optimum (ideal) amount of this medicine guided by certain blood tests. The investigators also know that not everyone responds to this therapy but do not understand the reasons for this variability between people. The CAMEO study has been started to help understand what factors are important in determining whether a child with CD completely heals the inflammation after anti-TNF therapy. The investigators will do that by measuring certain markers of inflammation in the blood and stoo…
This description comes directly from the study's public registry record.
Dena E Hopkins, MPH, CCRP · 860-545-8125 · CAMEO_CCC@connecticutchildrens.org
Jeffrey S Hyams, MD · 860-545-9560 · jhyams@connecticutchildrens.org
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| Phoenix Children's Hospital | Phoenix, Arizona, United States | Recruiting |
| Cedars-Sinai | Los Angeles, California, United States | Recruiting |
| Rady Children's Hospital - San Diego and University of California, San Diego | San Diego, California, United States | Active Not Recruiting |
| UCSF Benioff Children's Hospitals | San Francisco, California, United States | Recruiting |
| Connecticut Children's Medical Center | Hartford, Connecticut, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Riley Hospital for Children at Indiana University Health | Indianapolis, Indiana, United States | Recruiting |
| The Johns Hopkins Children's Medical Center | Baltimore, Maryland, United States | Recruiting |
| Boston Children's Hospital | Boston, Massachusetts, United States | Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Goryeb Children's Hospital/Morristown Medical Center/Atlantic Children's Health | Morristown, New Jersey, United States | Recruiting |
| Cohen Children's Medical Center of NY | Lake Success, New York, United States | Recruiting |
+ 14 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05781152