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Study identifier: NCT05779423 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cryoablation+Ipilimumab+Nivolumab in Melanoma

Condition: Metastatic Melanoma · Skin Cancer  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants37
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and effective for participants who have an unresectable melanoma that is resistant, or is growing, after receiving immunotherapy with a PD-1 inhibitor. The names of the study interventions involved in this study are: * Cryoablation (an interventional radiology procedure that freezes part of a tumor) * Ipilimumab (an immunotherapy) * Nivolumab (an immunotherapy)

This description comes directly from the study's public registry record.

Talk to the study team

Meghan J Mooradian, MD  ·  617-724-4000  ·  mmooradian@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General Hospital Cancer CenterBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05779423