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Study identifier: NCT05777278 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Savolitinib Plus Docetaxel as 2L in EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC With MET Overexpression

Condition: Non-small Cell Lung Cancer  ·  Sponsor: The First Affiliated Hospital of Guangzhou Medical University

PhasePhase 1/Phase 2
Planned participants29
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, pilot, single-arm, single-center study exploring the efficacy and safety of savolitinib plus docetaxel as second-line therapy in patients with MET overexpressed, EGFR/ALK/ROS1/MET ex14m-wildtype advanced NSCLC. Participants will receive treatment of docetaxel (60 mg/m2, ivgtt, q3w) in combination with savolitinib (300mg or 200mg according to safety run-in recommendation, p.o., BID) after informed consent signed. Treatment will continue until either objective disease progression, unacceptable toxicity occurs, consent is withdrawn, other discontinuation criterion is met, or study completion.

This description comes directly from the study's public registry record.

Talk to the study team

Jianxing He, M.D  ·  +86-20-83337792  ·  drjianxing.he@gmail.com

Wenhua Liang, M.D  ·  +86-13710249454  ·  liangwh1987@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05777278