← Eichor
Study identifier: NCT05776641 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

Condition: Alzheimer Disease · Family Members  ·  Sponsor: Massachusetts General Hospital

PhaseNA
Planned participants200
Who can joinAll sexes, 55 Years to 90 Years
Healthy volunteersYes

About this study

Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits (amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. Gamma waves are important for memory, and in patients with AD, there are fewer gamma waves in the brain. The Tsai lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only reduced amyloid and tau in the brain, but also improved memory. A light and sound device was developed for humans that stimulates the brain at 40Hz that can be used safely at home. The goal of this study is to see if using this device can prevent dementia in people who are at risk for developing Alzheimer's disease.

This description comes directly from the study's public registry record.

Talk to the study team

Angelina Singavarapu, BS  ·  617-258-7723  ·  gamma.wave@mit.edu

Ana Lipsanopoulos, MA  ·  617-258-7723  ·  anat13@mit.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Massachusetts Institute of TechnologyCambridge, Massachusetts, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05776641