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Study identifier: NCT05776563 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)

Condition: Diabetes Mellitus, Type 2  ·  Sponsor: Yale University

PhaseNA
Planned participants24
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control T2DM can be reversed with good glucose control. The main question\[s\] it aims to answer are: * To determine, whether abnormalities in brain glucose transport seen in individuals with uncontrolled diabetes, can be improved with better glucose control. * Assess which factors, (duration of diabetes mellitus (DM) and glycemic control) contribute to changes in glucose transport Participants will have: * A screening visit * placement of a continuous glucose monitor (CGM) 2 weeks before the first magnetic resonance spectroscopy (MRS) at week 0 * Additional visits/phone calls for intensification of diabetes management and nutrition visits * Second magnetic resonance spectroscopy (MRS) at week 12

This description comes directly from the study's public registry record.

Talk to the study team

Elizabeth Sanchez Rangel, MD  ·  203-785-6430  ·  elizabeth.sanchezrangel@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Yale New Haven Hospital (YNHH) Research Unit (HRU)New Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05776563