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Study identifier: NCT05775198 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome

Condition: Infertility, Female · IVF  ·  Sponsor: Nadezhda Women's Health Hospital

PhaseNA
Planned participants300
Who can joinFemale, 18 Years to 50 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy and live birth rates). To achieve this, blood will be obtained from eligible participants. Target cells will be isolated and incubated with the tested modulator for 24h, and returned to the uterine cavity 1 day prior to embryo transfer. Researchers will compare the reproductive outcome of the tested intervention to that of a control group who will not receive the investigated cell treatment prior to embryo transfer.

This description comes directly from the study's public registry record.

Talk to the study team

Dimitar Parvanov, PhD  ·  885944618  ·  dimparvanov@abv.bg

Always discuss trial participation with your own doctor first.

Locations (1)

Nadezhda Women's Health HospitalSofia, Sofia, BulgariaRecruiting

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Source record: clinicaltrials.gov/study/NCT05775198