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Study identifier: NCT05772897 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Parenting Skills Group for Mothers With Postpartum Depression

Condition: Postpartum Depression  ·  Sponsor: University of Colorado, Denver

PhaseNA
Planned participants750
Who can joinFemale, 18 Years to 50 Years
Healthy volunteersYes

About this study

The goal of this longitudinal study is to study the effects of a parenting skills group (Circle of Security Parenting, aka COSP) in mothers with postpartum depression. The main questions it aims to answer are: * Will changes in methylation of the OXTR rs53576 be apparent in mother and/or infant after having gone through the 8-week COSP program? * Will COSP participation be associated with improved symptoms of postpartum depression (over and above standard care), attachment style, and relational characteristics of the mother-infant dyad? * Will COSP participation be associated with changes in social behavior in the infant, and if so, do they persist throughout childhood? Participants will * Participate in an 8-week COSP program delivered remotely via Zoom. * Provide buccal swabs (mother and infant) to assess changes in methylation of OXTR rs53576 pre- versus post-intervention. * Complete a series of assessment questionnaires delivered remotely. * Videotape a play-based assessment in their home. * Receive infant developmental testing Researchers will compare characteristics of waitlist controls to those participating in the COSP program at the mid-way point of the program to see if the two groups differ.

This description comes directly from the study's public registry record.

Talk to the study team

Sunny Stophaeros, MS  ·  9253392971  ·  sunny.stophaeros@ucdenver.edu

Caroline R Harrison, MPH  ·  caroline.harrison@cuanschutz.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Colorado DenverDenver, Colorado, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05772897