Condition: Heart Failure · Coronary Artery Disease · Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences
According to modern concepts, mitochondrial dysfunction may be the fundamental basis for the development and progression of CHF, including in patients undergoing myocardial revascularization. The processes of mitochondrial fusion, division and mitophagy are aimed at maintaining cellular homeostasis. A change in the balance of these processes can lead to the accumulation of damaged organelles with impaired functions. In patients with CHF, dysfunctional mitochondria are characterized by size dispersion, crist disorganization, and localization changes relative to myofibrils. At the same time, the topic of the influence of mitochondrial dysfunction on the prognosis and clinical course of CHF remains debatable today. Direct study of the structural and functional features of mitochondria in human cardiomyocytes is an extremely difficult task, and therefore, such studies are carried out extremely rarely and on very limited cohorts. In the planned study, due to the long time of the study material recruitment, the ultrastructure of mitochondria in a large cohort of patients, ranging from 45 to 60 people, will be studied. The aim of this study is to study the association of mitochondrial dysfunction with the clinical course and outcomes of CHF of ischemic etiology, as well as to assess the degree of compliance of indirect criteria of mitochondrial dysfunction with direct ultrastructural characteristics of mitochondria in cardiomyocytes. This single-center prospective cohort study wi…
This description comes directly from the study's public registry record.
Elena A Kuzheleva, Ph.D. · +79234010502 · kea@cardio-tomsk.ru
Olga V Tukish, Ph.D. · +79069476343 · olgatukish@yandex.ru
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| Tomsk National Research Medical Center, Russian Academy of Sciences | Tomsk, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05770349