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Study identifier: NCT05770037 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers

Condition: Haematological Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders  ·  Sponsor: Cancer Research UK

PhasePhase 2/Phase 3
Planned participants30
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This clinical trial is looking at a drug called alectinib. Alectinib is approved as standard of care treatment for adult patients with certain types of lung cancer. This means it has gone through clinical trials and been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK. Alectinib works in lung cancer patients with a particular mutation in their cancer known as ALK. Investigators now wish to find out if it will be useful in treating patients with other cancer types which have the same mutation. If the results are positive, the study team will work with the NHS and the Cancer Drugs Fund to see if these drugs can be routinely accessed for patients in the future. This trial is part of a trial programme called DETERMINE. The programme will also look at other anti-cancer drugs in the same way, through matching the drug to rare cancer types or ones with specific mutations.

This description comes directly from the study's public registry record.

Talk to the study team

Aida Sarmiento Castro  ·  +44 207 242 0200  ·  determine@cancer.org.uk

Always discuss trial participation with your own doctor first.

Locations (27)

Belfast City HospitalBelfast, United KingdomRecruiting
University Hospital BirminghamBirmingham, United KingdomRecruiting
Birmingham Children's HospitalBirmingham, United KingdomNot Yet Recruiting
Bristol Royal Hospital for ChildrenBristol, United KingdomRecruiting
Bristol Haematology and Oncology CentreBristol, United KingdomRecruiting
Addenbrooke's HospitalCambridge, United KingdomRecruiting
Velindre Cancer CentreCardiff, United KingdomRecruiting
Cardiff Children's HospitalCardiff, United KingdomNot Yet Recruiting
Western General HospitalEdinburgh, United KingdomRecruiting
The Beatson HospitalGlasgow, United KingdomRecruiting
Royal Hospital for Children GlasgowGlasgow, United KingdomRecruiting
Leicester Royal InfirmaryLeicester, United KingdomRecruiting

+ 15 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05770037