Condition: Metastatic Microsatellite-stable Colorectal Cancer · Sponsor: Sun Yat-sen University
This is a randomized, controlled, multicenter phase Ⅲ study to evaluate the therapeutic efficacy and safety of chidamide + sintilimab + bevacizumab versus standard second-line FOLFIRI + bevacizumab therapy in subjects with advanced microsatellite stable colorectal cancer who have failed first-line oxaliplatin-containing standard therapy. The primary purpose is to compare the progression-free survival (PFS) of chidamide + sintilimab + bevacizumab versus standard second-line FOLFIRI + bevacizumab therapy for colorectal cancer, with a planned enrollment of 176 subjects with advanced microsatellite stable colorectal cancer who have failed first-line oxaliplatin-containing standard therapy.
This description comes directly from the study's public registry record.
Ruihua Xu, MD · +86 20 87343795 · xurh@sysucc.org.cn
Feng Wang, MD,PhD · +86 20 87343795 · wangfeng@sysucc.org.cn
Always discuss trial participation with your own doctor first.
| Anhui Provincial Cancer Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| The First People's Hospital of Foshan | Foshan, Guangdong, China | Not Yet Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Recruiting |
| The Third Affiliated Hospital of Sun Yat-sen University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The First Affiliated Hospital of Guangxi Medical University | Nanning, Guangxi, China | Not Yet Recruiting |
| Harbin Medical University Cancer Hospital | Harbin, Heilongjiang, China | Not Yet Recruiting |
| Henan Cancer Hospital | Zhengzhou, Henan, China | Not Yet Recruiting |
| The First Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, China | Not Yet Recruiting |
| Ruijin Hospital, Shanghai Jiaotong University School of Medicine | Shanghai, Shanghai Municipality, China | Not Yet Recruiting |
| West China Hospital of Sichuan University | Chengdu, Sichuan, China | Not Yet Recruiting |
| The Second Affiliated Hospital of Kunming Medical University | Kunming, Yunnan, China | Not Yet Recruiting |
| The First Affiliated Hospital of Zhejiang University College of Medicine | Hangzhou, Zhejiang, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05768503