Condition: Brain Metastases · Radiotherapy · EGFR Activating Mutation · Sponsor: Sun Yat-sen University
This is a prospective, multicenter, randomized, controlled clinical study of NSCLC patients with intracranial oligo-metastatic EGFR-sensitive mutations treated with EGFR-TKI Almonertinib , according to the implementation time of brain radiotherapy. Patients were randomly divided into two groups, experimental group (early intervention group of brain radiotherapy) : the brain radiotherapy started within 1 month of TKI treatment, the brain radiotherapy here specifically refers to stereotactic radiotherapy; Control group (brain radiotherapy late intervention group) : Brain radiotherapy was given within 3 months after brain progression during TKI treatment. The differences in OS,iPFS, PFS, iORR, safety, neurocognitive function and quality of life between the two groups were compared.
This description comes directly from the study's public registry record.
Likun Chen, Ph.D · +8613798019964 · chenlk@sysucc.org.cn
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| Sun-Yat-Sen university | Guangdong, Guangzhou, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05768490