Condition: AMI · STEMI · NSTEMI · Sponsor: Assistance Publique - Hôpitaux de Paris
Recent clinical trials have proven the cardiovascular benefits of new medications for patients with heart failure with reduced ejection fraction (HFrEF), especially sodium-glucose co-transporter 2 (SGLT2) inhibitors. There are no existing randomized clinical trials evaluating the efficacy and safety of dapagliflozin (nor any other SGLT2-inhibitor) to limit cardiac remodeling in patients with acute myocardial infarction (AMI) and left ventricular (LV) dysfunction. Preventing cardiac remodeling, an established predictor of subsequent heart failure (HF) and cardiovascular death, is likely to translate into benefit in reducing clinical events in post-MI patients.
This description comes directly from the study's public registry record.
Etienne PUYMIRAT, Pr · 00331.56.09.28.51 · etienne.puymirat@aphp.fr
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| Department of Cardiology AP-HP Hôpital européen Georges - Pompidou | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05764057