Condition: Cervical Cancer · Cervix Cancer · Cervix Neoplasm · Sponsor: Hospital do Coracao
This study hypothesizes that patients who persist with cell-free human papillomavirus deoxyribonucleic acid (cfHPV-DNA) plasma expression at the end of standard treatment, can derive the benefit of using adjuvant chemotherapy in locally advanced cervical cancer (CC). After standard treatment based on concomitant chemoradiotherapy regime, a qualitative and quantitative research of cfHPV-DNA in plasma of patients will be conducted. Patients who have positive research for plasma cfHPV-DNA at the end of chemoradiotherapy treatment will be randomized to receive two additional cycles of adjuvant chemotherapy or observation. Patients will be followed with conduction of computed tomography (CT) scan of the thorax and magnetic resonance (MRI) of abdomen and pelvis and clinical and gynecological examination at every four months.
This description comes directly from the study's public registry record.
Michelle S Almeida, PhD · 11 999112805 · malmeida@hcor.com.br
Rachel H Machado, MCS · 11 30536611 · rhelena@hcor.com.br
Always discuss trial participation with your own doctor first.
| Centro Integrado de Pesquisa da Amazônia, CINPAM | Manaus, Amazonas, Brazil | Recruiting |
| Hospital Evangélico de Cachoeiro de Itapemirim | Cachoeiro de Itapemirim, Espírito Santo, Brazil | Not Yet Recruiting |
| Hospital Samur | Vitória da Conquista, Estado de Bahia, Brazil | Not Yet Recruiting |
| Hospital de Base do Distrito Federal | Brasília, Federal District, Brazil | Not Yet Recruiting |
| Hospital do Câncer de Muriaé | Muriaé, Minas Gerais, Brazil | Recruiting |
| Centro de Oncologia de Cascavel, CEONC | Cascavel, Paraná, Brazil | Not Yet Recruiting |
| União Oeste Paranaense de Estudos e Combate ao Câncer, UOPECCAN | Cascavel, Paraná, Brazil | Not Yet Recruiting |
| Centro Integrado de Oncologia de Curitiba, CIONC | Curitiba, Paraná, Brazil | Not Yet Recruiting |
| Instituto Nacional do Câncer, INCA | Rio de Janeiro, Rio de Janeiro, Brazil | Recruiting |
| Liga Norte Riograndense Contra o Câncer | Natal, Rio Grande do Norte, Brazil | Not Yet Recruiting |
| Hospital Tacchini | Bento Gonçalves, Rio Grande do Sul, Brazil | Not Yet Recruiting |
| Hospital Geral de Caxias do Sul | Caxias do Sul, Rio Grande do Sul, Brazil | Not Yet Recruiting |
+ 14 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05764044