Condition: Early-stage Breast Cancer · HER2-positive Breast Cancer · Adjuvant Treatment After Trastuzumab · Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Neratinib is an irreversible pan-HER tyrosine kinase inhibitor (TKI). Currently, no studies have investigated the use of macromolecular anti-HER2 agents combined with TKIs for the treatment of non-pCR HER2-positive breast cancer following neoadjuvant therapy. Furthermore, there are no prospective randomized controlled trials comparing trastuzumab plus pertuzumab versus trastuzumab plus TKIs in HER2-positive breast cancer patients with residual cancer burden class (RCB) I or II after neoadjuvant trastuzumab and pertuzumab. Therefore, this study aimed to evaluate the efficacy and safety of adjuvant trastuzumab plus neratinib in patients with hormone receptor-positive/HER2-positive breast cancer and RCB 0/I following neoadjuvant trastuzumab and pertuzumab therapy.
This description comes directly from the study's public registry record.
Chang Gong · 13925089353 · gchang@mail.sysu.edu.cn
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| Sun Yat-sen University Sun Yat-sen Memorial Hospital | Guangzhou, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05760612