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Study identifier: NCT05756777 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Condition: Acute Myeloid Leukemia (AML)  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 1
Planned participants18
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to see if the combination of gilteritinib with ivosidenib or enasidenib is a safe and effective treatment for people with relapsed/refractory AML with FLT3/IDH1 or FLT3/IDH2 gene mutations. The researchers will also look for the highest dose of the combination of gilteritinib with ivosidenib or enasidenib that causes few or mild side effects. When the highest safe dose is found, they will test that dose in new groups of participants.

This description comes directly from the study's public registry record.

Talk to the study team

Eytan Stein, MD  ·  646-608-3749  ·  steine@mskcc.org

Aaron Goldberg, MD,PhD  ·  646-608-3752

Always discuss trial participation with your own doctor first.

Locations (7)

Memorial Sloan Kettering Basking RidgeBasking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering MonmouthMiddletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering BergenMontvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk-CommackCommack, New York, United StatesRecruiting
Memorial Sloan Kettering WestchesterHarrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering NassauUniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05756777