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Study identifier: NCT05753657 Synced from ClinicalTrials.gov · July 29, 2026
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A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.

Condition: Metastatic Breast Cancer · Hyperinsulinism · Hyperglycemia Drug Induced  ·  Sponsor: Rambam Health Care Campus

PhaseEARLY_Phase 1
Planned participants30
Who can joinFemale, 18 Years to 85 Years
Healthy volunteersNo

About this study

The goal of this study is to test whether monitoring insulin levels and using pioglitazone to treat hyperglycemia and hyperinsulinemia in patients treated with Alpelisib for metastatic breast cancer is feasible and safe, and to assess the rates of glycemic control, dose reductions and treatment discontinuation and the progression free survival of patients treated with this regimen.

This description comes directly from the study's public registry record.

Talk to the study team

Ayelet Shai, MD  ·  +972-4-777-6700  ·  a_shai@rambam.health.gov.il

Always discuss trial participation with your own doctor first.

Locations (1)

Rambam Health Care CampusHaifa, IsraelRecruiting

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Source record: clinicaltrials.gov/study/NCT05753657