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Study identifier: NCT05746039 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Feasibility of Semaglutide in Advanced Lung Disease

Condition: Obesity · Interstitial Lung Disease · Chronic Obstructive Pulmonary Disease  ·  Sponsor: University of Pennsylvania

PhasePhase 1/Phase 2
Planned participants8
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.

This description comes directly from the study's public registry record.

Talk to the study team

Michaela R Anderson, MD  ·  215-662-3202  ·  michaela.anderson@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Pennsylvania Perelman School of MedicinePhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05746039