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Study identifier: NCT05742607 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

Condition: Non Small Cell Lung Cancer  ·  Sponsor: Innate Pharma

PhasePhase 2
Planned participants70
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In Cohort 1, the study was intended to assess safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab, in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC). Study Design was updated following the results of interim analysis # 2 (protocol amendment, adding cohort 2). Cohort 2 includes patients with resectable Stage II to IIIB NSCLC expressing PD-L1 ≥1%, receiving (only) neoadjuvant IPH5201+ durvalumab + chemotherapy

This description comes directly from the study's public registry record.

Talk to the study team

Innate Pharma  ·  +33484903084  ·  clinical.trials@innate-pharma.fr

Always discuss trial participation with your own doctor first.

Locations (30)

St. Anthony's Hospital - BayCare Health SystemSt. Petersburg, Florida, United StatesTerminated
H. Lee Moffitt Cancer Center & Research InstituteTampa, Florida, United StatesTerminated
University of Chicago Medical CenterChicago, Illinois, United StatesWithdrawn
Northwell Health Cancer Institute / Center for Novel Cancer TherapeuticsLake Success, New York, United StatesWithdrawn
Millennium Research & Clinical DevelopmentHouston, Texas, United StatesTerminated
UW Carbone Cancer Center - Cancer ConnectMadison, Wisconsin, United StatesTerminated
Angers University Hospital CenterAngers, FranceTerminated
University Hospital Center CaenCaen, FranceTerminated
Hospital CalmetteLille, FranceNot Yet Recruiting
CHU de LimogesLimoges, FranceRecruiting
Leon Berard CenterLyon, FranceRecruiting
Marseille University Hospital Center - North HospitalMarseille, FranceRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05742607