Condition: Sickle Cell Disease · Thalassemia, Beta · Thalassemia · Sponsor: Memorial Sloan Kettering Cancer Center
Hematopoietic Cell Transplantation/HCT involves receiving healthy blood-forming cells (stem cells) from a donor to replace the diseased or damaged cells in participants' bone marrow. The researchers think giving participants treatment with fludarabine and dexamethasone, drugs that lower the activity of the body's immune system (immune suppression), before standard conditioning therapy and HCT may help prevent serious side effects, including graft failure and GvHD. In this study, depending on how participants' body responds to the fludarabine and dexamethasone, the study doctor may decide participants should receive another drug, called cyclophosphamide, instead of fludarabine. In addition, depending on the results of participants' routine blood tests, participants may receive the drugs bortezomib and rituximab, which also help with immune suppression.
This description comes directly from the study's public registry record.
Maria Cancio, MD · 212-639-2446 · canciom@mskcc.org
Jaap Jan Boelens, MD, PhD · 212-639-3643 · boelensj@mskcc.org
Always discuss trial participation with your own doctor first.
| Memorial Sloan Kettering at Basking Ridge (Consent only) | Basking Ridge, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Monmouth (Consent only) | Middletown, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Bergen (Consent only) | Montvale, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Suffolk - Commack (Consent only) | Commack, New York, United States | Recruiting |
| Memorial Sloan Kettering Westchester (Consent only) | Harrison, New York, United States | Recruiting |
| Memorial Sloan Kettering Nassau (All protocol activities) | Rockville Centre, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05736419