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Study identifier: NCT05733676 Synced from ClinicalTrials.gov · July 29, 2026
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Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment

Condition: White Spot Lesions · Orthodontic Appliance Complication · Caries Arrested  ·  Sponsor: University of Alberta

PhaseNA
Planned participants62
Who can joinAll sexes, 12 Years to 21 Years
Healthy volunteersYes

About this study

Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.

This description comes directly from the study's public registry record.

Talk to the study team

Ida M Kornerup, DMD, MEd  ·  780 492 7100  ·  kornerup@ualberta.ca

Nancy Abdelhay, DMD, PhD  ·  780 492 7100  ·  abdelhay@ualberta.ca

Always discuss trial participation with your own doctor first.

Locations (1)

KAYE Edmonton ClinicEdmonton, Alberta, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05733676