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Study identifier: NCT05733598 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

Condition: Hepatocellular Carcinoma · Biliary Tract Cancer  ·  Sponsor: Replimune, Inc.

PhasePhase 2
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the efficacy and safety of RP2 in combination with atezolizumab plus bevacizumab (Cohorts 1a and 1b) and RP2 monotherapy (Cohort 2) in the as second line treatment in patients with locally advanced unresectable, recurrent, and/or metastatic HCC and in combination with durvalumab as treatment in patients with unresectable locally advanced or metastatic BTC.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials at Replimune  ·  1-781-222-9570  ·  hccstudy@replimune.com

Clinical Trials at Replimune  ·  +44 1235 242 488  ·  hccstudy@replimune.com

Always discuss trial participation with your own doctor first.

Locations (12)

Beverly Hills Cancer CenterBeverly Hills, California, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Sylvester Comprehensive Cancer Center (University of Miami Hospital and Clinics)Miami, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
University of Maryland Medical CenterBaltimore, Maryland, United StatesRecruiting
Roswell Park Comprehensive Cancer CenterBuffalo, New York, United StatesRecruiting
Montefiore Medical CenterMontefiore Medical ParkThe Bronx, New York, United StatesRecruiting
University of Pennsylvania, Abramson Cancer CenterPhiladelphia, Pennsylvania, United StatesRecruiting
UPMC Hillman Cancer CenterPittsburgh, Pennsylvania, United StatesRecruiting
The West ClinicGermantown, Tennessee, United StatesRecruiting
University of Tennessee Medical CenterKnoxville, Tennessee, United StatesRecruiting
Houston Methodist Hospital Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05733598