Condition: Osteoporosis · Osteoarthritis · Bone Diseases · Sponsor: Relation Therapeutics
Diseases of bone associated with ageing, including osteoporosis (OP) and osteoarthritis (OA), reduce bone mass, bone strength and joint integrity. Current non-surgical approaches are limited to pharmaceutical agents that are not disease modifying and have poor patient tolerability due to side effect profiles. Developing a fundamental understanding of cellular bone homeostasis, including how key cell types affect tissue health, and offering novel therapeutic targets for prevention of bone disease is therefore essential. This is the focus of OSTEOMICS. A number of factors have been linked to increased risk of bone disease, including genetic predisposition, diet, smoking, ageing, autoimmune disorders and endocrine disorders. In our study, we will recruit patients undergoing elective and non-elective orthopaedic surgery and obtain surgical bone waste for analysis. This will capture a cohort of patients with bone disorders like OP and OA, in addition to patients without overt clinical bone disease. We will study the relationship between the molecular biology of bone cells, bone structure, genetics (DNA) and environmental factors with the aim of identifying and validating novel therapeutic targets. We will leverage modern single cell technologies to understand the diversity of cell types found in bone. These technologies have now led to the characterisation of virtually every tissue in the body, however bone and bone-adjacent tissues are massively underrepresented due to the anat…
This description comes directly from the study's public registry record.
Jake Taylor-King, DPhil · 447387227904 · jake@relationrx.com
Susan O'Connor · 07513017280 · susan.oconnor@blctrials.onmicrosoft.com
Always discuss trial participation with your own doctor first.
| Harley Street Specialist Hospital | London, Greater London, United Kingdom | Active Not Recruiting |
| Barts Health NHS Trust | London, United Kingdom | Recruiting |
| Chase Farm Hospital | London, United Kingdom | Recruiting |
| Fitzrovia Hospital/QASMC | London, United Kingdom | Recruiting |
| King's College Hospital | London, United Kingdom | Not Yet Recruiting |
| Luton & Dunstable University Hospital | London, United Kingdom | Active Not Recruiting |
| Royal National Orthopaedic Hospital NHS Trust | London, United Kingdom | Not Yet Recruiting |
| West Middlesex University Hospital | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05732870