Condition: Colorectal Cancer · Early Onset Colorectal Cancer · Diet Habit · Sponsor: San Raffaele University
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants, obesity, alcohol, physical activity, red meat, and a Western diet). Design: an international, multicenter, retrospective case-control study of prospectively enrolled patients; low-risk intervention study as it will perform a fecal occult blood test Endpoint: predictive power of a semi-quantitative food frequency questionnaire (SQFFQ) developed for eoCRC. Cases: Patients with a recent diagnosis of eoCRC (within 2 years from enrollment). Controls: matched by age (matching range ± 5 years) and sex. Healthy volunteers will be mainly enrolled among workers within the participating hospital center. The enrolled healthy volunteers will perform a fecal occult blood test. Variables of interest: age, sex, ethnicity, BMI at the time of eoCRC diagnosis and at 18 years old, country, tobacco smoking at the time of eoCRC diagnosis and at 18 years old, sitting time, TV-viewing time, moderate-to-vigorous physical activity (MVPA), waist circumference (cm), home blood pressure levels (mmHg), fasting blood glucose (mg/dl), regular consumption of aspirin/NSAID, calcium and folate supplements, oral contraceptive agents, post-menopausal hormones and years of consumptions, if the filled questionnaire reflects diet for the last 5-10 years before. Cases only: date of eoCRC diag…
This description comes directly from the study's public registry record.
Giulia Martina Cavestro, MD PhD · 0226435508 · cavestro.giuliamartina@hsr.it
Always discuss trial participation with your own doctor first.
| Department of Medicine-Gastroenterology, Denver Veterans Affairs Medical Center, University of Colorado Hospital | Denver, Colorado, United States | Recruiting |
| Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Chicago Medicine | Chicago, Illinois, United States | Recruiting |
| Department of Gastrointestinal Surgery, Helsinki University Hospital | Helsinki, Finland | Recruiting |
| Department of General, Visceral and Transplant Surgery, Hospital of the University of Munich (LMU) | Munich, Germany | Recruiting |
| Gabriela Moslein | Wuppertal, Germany | Recruiting |
| Prof Giulia Martina Cavestro, MD PhD | Milan, Lombardy, Italy | Recruiting |
| Division of Cancer Medicine, Oslo University Hospital (OUS), Institute for Cancer Genetics and Informatics Norwegian Radium Hospital | Oslo, Norway | Recruiting |
| Department of Gastroenterology, Hospital Clínic de Barcelona, University of Barcelona | Barcelona, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05732623