Condition: Alcohol Use Disorder · Sponsor: Johns Hopkins University
The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cerebellar, VTA and other brain reward structures? 3. What is the therapeutic potential of cerebellar transcranial direct current stimulation (tDCS) for modulating alcohol cue reactivity, associated alcohol craving, and cerebellar - VTA functional connectivity in the brain reward system? Persons with AUD will be compared with healthy control participants.
This description comes directly from the study's public registry record.
John E Desmond, PhD · 410-502-3583 · jdesmon2@jhmi.edu
JoAnna Mathena
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| Johns Hopkins University School of Medicine | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05732207