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Study identifier: NCT05731622 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Effect of a SI-MMC on the IVR Rate After Ureteroscopy for UTUC

Condition: Upper Urinary Tract Carcinoma  ·  Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

PhaseN/A
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this observational study is to evaluate the intravesical recurrence (IVR) rate after ureteroscopy (diagnostic or treatment) for upper tract urothelial carcinoma (UTUC) followed by an adjuvant single instillation of Mitomycin C (SI-MMC). The main question it aims to answer are: * What is the total and time to IVR after 2 years after ureteroscopy (diagnostic or treatment) for UTUC * How is the IVR compared with a historical cohort (no SI-MMC) * What is the time to IVR after 2 years in patients who subsequently received treatment by endoscopy vs. radical nephroureterectomy (RNU) * What is the additional value of a SI-MMC on time to IVR after RNU + adjuvant MMC in patients who were evaluated by ureteroscopy prior to RNU

This description comes directly from the study's public registry record.

Talk to the study team

Joyce Baard, MD, MSc  ·  +31 020 444 0261  ·  j.baard@amsterdamumc.nl

Orlane Figaroa, MD  ·  +31 020 444 0261  ·  o.j.figaroa@amsterdamumc.nl

Always discuss trial participation with your own doctor first.

Locations (1)

AmsterdamUMCAmsterdam, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05731622