Condition: Bronchiectasis · Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Bronchiectasis is a chronic inflammatory respiratory disease defined as the irreversible dilatation of one or more bronchi and is associated with chronic and frequently purulent expectoration, multiple exacerbations and progressive dyspnea. Bronchiectasis has a large heterogeneity. Different patients with bronchiectasis may have different etiology, clinical manifestations, and imaging features. Previous studies showed that there are significant relationship between the airway microbiome and the severity of the disease. For example, patient with airway Pseudomonas aeruginosa colonization has heavier symptoms, heavier severity, poorer quality of life, more acute exacerbations, and worse prognosis. A large number of studies have reported that long-term treatment of low-dose macrolides such as azithromycin or clarithromycin has anti-inflammatory and immunomodulatory effects, which can improve the clinical symptoms and disease progression of various chronic airway diseases, such as diffuse panbronchiolitis, chronic obstructive pulmonary disease, bronchiectasis. Both the 2017 European Respiratory Society guidelines and the 2019 British Thoracic Society Guideline recommend macrolide drugs for the treatment of chronic Pseudomonas aeruginosa colonization bronchiectasis or frequent acute exacerbations bronchiectasis, but the specific mechanism is unknown.This study is based on omics methods (Microbiology and Metabolomics) to deeply explore the composition of airway and gut microbiota i…
This description comes directly from the study's public registry record.
Xiaorong Wang · 18627195231 · rong-100@163.com
Yaya Zhou · 15972916036 · 749833758@qq.com
Always discuss trial participation with your own doctor first.
| Guizhou Provincial people's Hospital | Guiyang, Guizhou, China | Recruiting |
| Wuhan Union Hospital | Wuhan, Hubei, China | Recruiting |
| Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital | Yichang, Hubei, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05731427