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Study identifier: NCT05722938 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)

Condition: Community-acquired Pneumonia  ·  Sponsor: Biotest

PhasePhase 3
Planned participants590
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main objective of the trial is to assess the efficacy and safety of trimodulin as adjunctive treatment to standard of care (SoC) compared to placebo plus SoC in hospitalized subjects with sCAP on invasive mechanical ventilation (IMV). Other objectives are to determine detailed pharmacokinetic (PK) properties of trimodulin in a PK substudy and to determine its pharmacodynamic (PD) properties.

This description comes directly from the study's public registry record.

Talk to the study team

Patrick Langohr  ·  +491732947122  ·  patrick.langohr@biotest.com

Claudia Schulte  ·  +4915222801491  ·  claudia.schulte@biotest.com

Always discuss trial participation with your own doctor first.

Locations (154)

Pulmonary Associates of Mobile, P.C.Mobile, Alabama, United StatesWithdrawn
University of California San Francisco-FresnoFresno, California, United StatesRecruiting
UC Davis HealthSacramento, California, United StatesWithdrawn
Augusta UniversityAugusta, Georgia, United StatesWithdrawn
Sparrow Clinical Research InstituteLansing, Michigan, United StatesWithdrawn
William Beaumont HospitalRoyal Oak, Michigan, United StatesWithdrawn
University of Missouri Clinical Research CenterColumbia, Missouri, United StatesWithdrawn
Hannibal ClinicHannibal, Missouri, United StatesWithdrawn
Mercury Street Medical GroupButte, Montana, United StatesWithdrawn
St. Michael's Medical CenterNewark, New Jersey, United StatesWithdrawn
Buffalo VA Medical CenterBuffalo, New York, United StatesWithdrawn
Lenox Hill HospitalNew York, New York, United StatesRecruiting

+ 142 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05722938