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Study identifier: NCT05722002 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

Condition: Surgery · Pain, Postoperative  ·  Sponsor: University of Michigan

PhasePhase 4
Planned participants900
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.

This description comes directly from the study's public registry record.

Talk to the study team

Sarah Clark, BA  ·  734-232-0324  ·  sarahmcl@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (8)

University of MichiganAnn Arbor, Michigan, United StatesRecruiting
Henry Ford Health SystemDetroit, Michigan, United StatesRecruiting
Washington University in Saint LouisSt Louis, Missouri, United StatesRecruiting
Cooper University Health CareCamden, New Jersey, United StatesRecruiting
University of North Carolina HospitalsChapel Hill, North Carolina, United StatesRecruiting
Temple University - Temple HealthPhiladelphia, Pennsylvania, United StatesRecruiting
Women's College HospitalToronto, Ontario, CanadaRecruiting
Unity Health TorontoToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05722002