Condition: Parkinson Disease · REM Sleep Behavior Disorder · Sponsor: IRCCS San Raffaele
The genetic complexity and heterogeneity of the sporadic forms of Parkinson's disease (PD) are posing a formidable challenge to disentangle their direct molecular causes. To advance this research, we plan to coordinate our local biorepositories of PD biological specimens creating a standardized and integrated national resource. In this framework, we plan to collect more samples from additional sporadic PD cases and to extend the sampling to patients with REM sleep behavior disease. We plan a large campaign of whole genome sequencing including about 200 patients to identify rare genomic variants plausibly associated with these diseases. In addition, we will standardize the generation and quality control of iPSC lines to make available to the scientific community. Finally, we will combine iPSC technology and gene editing to functionally assess the relative impact of rare variants in coding regions inherited together as a polygenic trait previously identified in selected sporadic PD cases
This description comes directly from the study's public registry record.
Vania Broccoli, PhD · +39 0226434616 · broccoli.vania@hsr.it
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| IRCCS San Raffaele | Milan, Italy, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05721911