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Study identifier: NCT05720130 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase Ib/IIa Dose Escalation and Expansion Study of [²¹²Pb]Pb-ADVC001 in Metastatic Prostate Cancer (TheraPb - Phase I/II Study).

Condition: Prostate Cancer · Metastatic Castration-resistant Prostate Cancer · Metastatic Hormone Sensitive Prostate Cancer  ·  Sponsor: AdvanCell Pty Limited

PhasePhase 1/Phase 2
Planned participants100
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, open-label, dose-escalation and randomized dose optimization and expansion study. The Phase Ib portion of the study aims to determine the safety and tolerability of escalating doses of \[212Pb\]Pb-ADVC001 administered every 6, 4, 2 or 1 week(s) and establish the recommended phase 2 doses (RP2D). The Phase 2a expansion aims to assess the efficacy and safety of \[212Pb\]Pb-ADVC001 at the RP2 doses in 3 participant groups.

This description comes directly from the study's public registry record.

Talk to the study team

Anna Karmann  ·  612 8000 4199  ·  contact@advancell.com.au

Always discuss trial participation with your own doctor first.

Locations (3)

Royal Brisbane & Women's HospitalBrisbane, Queensland, AustraliaRecruiting
Princess Alexandra HospitalBrisbane, Queensland, AustraliaRecruiting
Gold Coast University HospitalSouthport, Queensland, AustraliaRecruiting

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Source record: clinicaltrials.gov/study/NCT05720130