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Study identifier: NCT05718323 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Niraparib Added to Anti-PD-L1 Antibody Maintenance in SLFN11-positive, Extensive-disease SCLC

Condition: SCLC,Extensive Stage · SLFN11-positive  ·  Sponsor: ETOP IBCSG Partners Foundation

PhasePhase 2
Planned participants44
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

RAISE is an international, multicentre, single-arm phase II trial. The trial treatment consists of the addition of niraparib, 200 mg orally once daily to anti-PD-L1 antibody maintenance. The primary objective of this trial is to assess the clinical efficacy of the addition of niraparib to anti-PD-L1 monoclonal antibody maintenance treatment in patients with SLFN11-positive ED-SCLC which has not progressed following standard first-line chemo-immunotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Heidi Roschitzki, PhD  ·  +41 31 511 94 00  ·  heidi.roschitzki@etop.ibcsg.org

Susanne Roux  ·  RAISE@etop.ibcsg.org

Always discuss trial participation with your own doctor first.

Locations (18)

CHU - AngersAngers, FranceRecruiting
Centre Hospitalier d'AvignonAvignon, FranceRecruiting
Caen - CHUCaen, FranceRecruiting
Lyon - Centre Léon BérardLyon, FranceNot Yet Recruiting
LMU Klinikum / Thoracic Oncology center MünichMünchen, GermanyRecruiting
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)Meldola, ItalyRecruiting
Instituto Europeo di Oncologia (IEO)Milan, ItalyNot Yet Recruiting
Santa Maria della Misericordia HospitalPerugia, ItalyRecruiting
Complejo Hospitalario Universitario a CoruñaA Coruña, SpainNot Yet Recruiting
Complejo Hospitalario de JaénJaén, SpainRecruiting
Hospital Universitario Puerta de HierroMadrid, SpainRecruiting
Kantonsspital BadenBaden, SwitzerlandRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05718323