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Study identifier: NCT05713838 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery

Condition: Esophagus Adenocarcinoma  ·  Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

PhasePhase 2
Planned participants32
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The present clinical trial is a prospective, investigator-initiated, single-arm, open-label, multicenter phase II trial investigating whether a definite organ preservation therapy consisting of the combination of durvalumab with chemoradiation is an efficient and safe treatment option for early stage, cT1 and cT2N0, esophageal adenocarcinoma with indication for radical surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Thorsten Götze, Prof. Dr.  ·  +496976014187  ·  goetze.thorsten@khnw.de

Ulas Tenekeci, Dr.  ·  +49 69 589978764  ·  tenekeci.ulas@ikf-khnw.de

Always discuss trial participation with your own doctor first.

Locations (22)

Klinikum St. Marien Kommunalunternehmen - Anstalt des öffentlichen Rechts der Stadt AmbergAmberg, GermanyRecruiting
HELIOS Klinikum Bad SaarowBad Saarow, GermanyRecruiting
Charite Univeristätsmedizin BerlinBerlin, GermanyNot Yet Recruiting
Universitätsklinikum Brandenburg an der Havel Medizinische Hochschule BrandenburgBrandenburg an der Havel, GermanyRecruiting
Krankenhaus St. Joseph-Stift GmbHBremen, GermanyRecruiting
Klinikum Darmstadt GmbHDarmstadt, GermanyNot Yet Recruiting
Kliniken Essen Mitte Klinik für Internistische Onkologie und HämatologieEssen, GermanyRecruiting
Institute of Clinical Cancer Research, University Cancer Center (UCT) Frankfurt Krankenhaus NordwestFrankfurt, GermanyRecruiting
Universitätsmedizin GöttingenGöttingen, GermanyRecruiting
Universitätsklinikum Halle (Saale) Universitätsklinik und Poliklinik für Innere Medizin IHalle, GermanyRecruiting
Universitätsklinikum Heidelberg, RadioOnkologie & StrahlentherapieHeidelberg, GermanyRecruiting
St. Elisabeth Gruppe GmbH, St. Anna Hospital HerneHerne, GermanyRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05713838