Condition: Locally Advanced Head and Neck Carcinoma · Sponsor: Centre Jean Perrin
Sixty percent of newly diagnosed head and neck squamous cell carcinomas (HNSCCs) are at a locally advanced (LA) stage. Depending on tumor site, stage, and resectability, locoregional failure rates can range from 35% to 65%. The persistence of residual disease at the end of treatment is a major prognostic element but is not always reliably assessed by current imaging techniques. Up to 40-50% of patients have residual adenomegaly and only 30% have viable disease when further adenectomy is performed. Sensitive and reproducible detection of residual disease after treatment is a major challenge in this patient category. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) guided surveillance, with a negative predictive value of 95-97%, has proven to be non-inferior to cervical curage in HNSCCs with residual adenomegaly. Cervical curage is now indicated only if the response assessed by PET-CT is incomplete. Nevertheless, the ability of PET-CT to predict treatment failure is unsatisfactory due to a high frequency of false positives, because of inflammatory changes, with a positive predictive value of about 20-50%. Circulating tumor DNA (ctDNA) may provide a more reliable assessment of response to potentiated radiotherapy. Liquid biopsy monitoring of response in patients treated with potentiated radiation therapy for locally advanced HNSCCs a has been shown to be feasible. In 85% of patients, ctDNA is detectable and correlates significantly wit…
This description comes directly from the study's public registry record.
Angeline GINZAC COUVÉ, PhD · 0463663337 · angeline.ginzac@clermont.unicancer.fr
Always discuss trial participation with your own doctor first.
| Centre Jean PERRIN | Clermont-Ferrand, Puy-de-Dôme, France | Recruiting |
| Centre Hospitalier Henri Mondor | Aurillac, France | Not Yet Recruiting |
| Hôpital de la Croix-Rousse | Lyon, France | Recruiting |
| CHU de Saint-Étienne | Saint-Etienne, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05710679