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Study identifier: NCT05709496 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dose De-escalation in Prostate Radiotherapy Using the MRL

Condition: Prostate Adenocarcinoma  ·  Sponsor: Royal Marsden NHS Foundation Trust

PhaseNA
Planned participants20
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this feasibility study is to learn about dose de-escalation in the treatment of men with intermediate risk prostate cancer. The main question it aims to answer is the technical feasibility of treating prostate cancer with toxicity-minimising radiotherapy on an Magnetic Resonance Linear Accelerator (MR-linac). It will also examine gastrointestinal and genitourinary toxicity in the acute and late setting post radiotherapy as well as Prostate-Specific antigen (PSA) control up until 2 years post treatment. Participants will be treated with radiotherapy to the prostate with which will be given in 30Gy in 5 fractions to the whole prostate and 45Gy in 5 fractions to the dominant lesion.

This description comes directly from the study's public registry record.

Talk to the study team

Alison Tree, MBBS  ·  02086613269  ·  alison.tree@icr.ac.uk

Rosalyne L Westley, MBchB  ·  07731300755  ·  rosalyne.westley@rmh.nhs.uk

Always discuss trial participation with your own doctor first.

Locations (1)

The Royal Marsden HospitalSutton, Surrey, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT05709496