Condition: Birth Weight · Sponsor: London School of Hygiene and Tropical Medicine
Background: This programme effectiveness study responds to the need for evidence on the effect on birthweight of switching from iron-folic acid supplementation (IFA) to multiple micronutrient supplementation (MMS) as part of routine antenatal care in Ethiopia. A 2019 meta-analysis of trial data reported a mean improvement of 35g in newborn birthweight amongst newborns born to women who took MMS in pregnancy compared to those who took IFA. Responding to this evidence, in 2020 the World Health Organisation updated its global guideline on MMS from 'not recommended' to 'recommended in the context of rigorous research'. The guideline identifies priority research being 'to establish the impact of switching routine antenatal IFA to MMS on important health outcomes, equity, acceptability, feasibility, sustainability and health-care resources in different country settings.' In 2022 the Ministry of Health of Ethiopia (MoH), will change from MMS to IFA in a set of pilot districts. EPHI and LSHTM have been asked to evaluate the effect of this change on mean birthweight and propose the current trial for this purpose. The overall aim is to evaluate the programme effectiveness on mean birthweight of providing MMS as part of routine antenatal care, compared to providing IFA. Findings will support the MoH to make evidence-informed decisions about the large-scale implementation of MMS in Ethiopia and also contribute to the global evidence base on the effectiveness of MMS in a programmatic se…
This description comes directly from the study's public registry record.
Tanya Marchant, PhD · +44 (0)7713088730 · tanya.marchant@lshtm.ac.uk
Masresha Tassema, PhD · +251 91 9782082 · dr.masresha.tessema@gmail.com
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| Gambella | Ītang, Gambella Region, Ethiopia | Recruiting |
| Oromia | Gīmbīcho, Oromiya, Ethiopia | Recruiting |
| Sidama | Bona Gena, Sidama Region, Ethiopia | Recruiting |
| SNNPR | Dara, Snnpr Region, Ethiopia | Recruiting |
| Somali | Āwarē, Somali, Ethiopia | Recruiting |
| Ethiopia Public Health Institute | Addis Ababa, Ethiopia | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05708183